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General Medicine · Electrolytes
Sample itemA patient with end-stage kidney disease who missed dialysis has potassium of 7.2 mmol/L, peaked T waves and a widened QRS. Which drug is given first?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Intravenous calcium gluconate
With ECG changes, hyperkalaemia is life-threatening and the first priority is to protect the myocardium. Intravenous calcium stabilises the cardiac membrane within minutes without lowering potassium, and insulin-dextrose, salbutamol and dialysis then remove or shift the potassium.
Option by option
A. Intravenous calcium gluconate (correct)
Correct. Calcium antagonises the membrane effects and prevents arrhythmia.
B. Intravenous insulin with dextrose
Insulin with dextrose shifts potassium into cells but does not stabilise the membrane and is given after calcium.
C. Oral sodium polystyrene resin
Resins remove potassium slowly over hours and are too slow for an emergency.
D. Nebulised salbutamol
Salbutamol shifts potassium modestly and is an adjunct, not the first protective step.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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