Papulosquamous disorders: steatocystoma multiplex: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Papulosquamous disorders: steatocystoma multiplex

Sample item

A teenage boy has dozens of firm, yellowish dome-shaped cysts on the chest and axillae, from the age of 12. When punctured they release an oily, clear fluid. Which gene is usually mutated?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. KRT17

Steatocystoma multiplex is an autosomal dominant condition with many sebaceous cysts. It is caused by mutations in keratin 17, which also underlies pachyonychia congenita type 2.

Option by option

  • A. FLG

    FLG loss of function causes ichthyosis vulgaris and atopy.

  • B. KRT5

    KRT5 mutations cause epidermolysis bullosa simplex.

  • C. KRT10

    KRT10 mutations cause epidermolytic hyperkeratosis.

  • D. KRT17 (correct)

    Correct. KRT17 mutations underlie steatocystoma multiplex.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is D, KRT17. Steatocystoma multiplex is an autosomal dominant condition with many sebaceous cysts.

Why is "FLG" not the answer?

FLG loss of function causes ichthyosis vulgaris and atopy.

Why is "KRT5" not the answer?

KRT5 mutations cause epidermolysis bullosa simplex.

Why is "KRT10" not the answer?

KRT10 mutations cause epidermolytic hyperkeratosis.

What concept does this question test?

It tests Papulosquamous disorders: steatocystoma multiplex in Dermatology. It is caused by mutations in keratin 17, which also underlies pachyonychia congenita type 2.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Papulosquamous disorders: steatocystoma multiplex?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.