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Dermatology · Infections: bacterial, viral, fungal, parasitic: gram-negative folliculitis
Sample itemA 22-year-old on long-term oral doxycycline for acne has a sudden crop of pustules and cysts around the nose and cheeks that do not respond to the antibiotic. Gram stain of pus shows gram-negative rods. Which organisms are responsible?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Klebsiella or Enterobacter species
Gram-negative folliculitis is a complication of prolonged antibiotic therapy for acne, from nasal colonisation by Klebsiella, Enterobacter or Proteus. The antibiotic is stopped, and oral isotretinoin is the usual treatment.
Option by option
A. Malassezia furfur
Malassezia is a yeast and causes pityrosporum folliculitis.
B. Staphylococcus aureus
Staphylococcus aureus is gram-positive and would be suppressed by doxycycline.
C. Klebsiella or Enterobacter species (correct)
Correct. Klebsiella and Enterobacter overgrow in the nose after prolonged tetracycline.
D. Cutibacterium acnes
Cutibacterium acnes is gram-positive and causes ordinary acne.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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