Systemic pathology: cardiovascular, respiratory, GI, renal, endocrine, CNS, bone and soft tissue: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Systemic pathology: cardiovascular, respiratory, GI, renal, endocrine, CNS, bone and soft tissue

Sample item

A 35-year-old man has gynaecomastia and a testicular mass with a golden-brown cut surface. Histology shows polygonal cells with eosinophilic cytoplasm containing rod-shaped crystalloids. What is the tumour?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Leydig cell tumour

Leydig cell tumours secrete androgens and sometimes oestrogens, and the Reinke crystalloids are characteristic. The yellow-brown colour comes from lipid and lipochrome.

Option by option

  • A. Seminoma

    Seminoma shows clear cells with lymphocytes and a fleshy homogeneous cut surface.

  • B. Yolk sac tumour

    Yolk sac tumour shows Schiller-Duval bodies and a raised AFP, in infants or mixed tumours.

  • C. Sertoli cell tumour

    Sertoli cell tumour forms tubules of columnar cells and lacks Reinke crystals.

  • D. Leydig cell tumour (correct)

    Correct. Reinke crystals in a golden-brown tumour identify Leydig cells.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is D, Leydig cell tumour. Leydig cell tumours secrete androgens and sometimes oestrogens, and the Reinke crystalloids are characteristic.

Why is "Seminoma" not the answer?

Seminoma shows clear cells with lymphocytes and a fleshy homogeneous cut surface.

Why is "Yolk sac tumour" not the answer?

Yolk sac tumour shows Schiller-Duval bodies and a raised AFP, in infants or mixed tumours.

Why is "Sertoli cell tumour" not the answer?

Sertoli cell tumour forms tubules of columnar cells and lacks Reinke crystals.

What concept does this question test?

It tests Systemic pathology: cardiovascular, respiratory, GI, renal, endocrine, CNS, bone and soft tissue in Pathology. The yellow-brown colour comes from lipid and lipochrome.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Systemic pathology: cardiovascular, respiratory, GI, renal, endocrine, CNS, bone and soft tissue?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.