Systemic pathology: cardiovascular, respiratory, GI, renal, endocrine, CNS, bone and soft tissue: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Systemic pathology: cardiovascular, respiratory, GI, renal, endocrine, CNS, bone and soft tissue

Sample item

A 65-year-old woman has a firm, solid, unilateral ovarian mass found incidentally. Histology shows nests of transitional-type epithelial cells with grooved, coffee-bean nuclei in a fibrous stroma. What is the tumour?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Brenner tumour

Brenner tumour is a surface epithelial-stromal tumour with urothelial-like nests, thought to arise from Walthard cell rests. Most are benign and found in postmenopausal women.

Option by option

  • A. Serous cystadenofibroma

    Serous cystadenofibroma has ciliated tubal-type epithelium over a fibrous core, not transitional nests.

  • B. Mucinous cystadenoma

    Mucinous cystadenoma is a multiloculated cyst lined by tall mucin-secreting cells.

  • C. Thecoma

    Thecoma is a sex cord-stromal tumour of spindle cells with lipid and oestrogen production.

  • D. Brenner tumour (correct)

    Correct. Urothelial-type nests with coffee-bean nuclei in fibrous stroma define Brenner tumour.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is D, Brenner tumour. Brenner tumour is a surface epithelial-stromal tumour with urothelial-like nests, thought to arise from Walthard cell rests.

Why is "Serous cystadenofibroma" not the answer?

Serous cystadenofibroma has ciliated tubal-type epithelium over a fibrous core, not transitional nests.

Why is "Mucinous cystadenoma" not the answer?

Mucinous cystadenoma is a multiloculated cyst lined by tall mucin-secreting cells.

Why is "Thecoma" not the answer?

Thecoma is a sex cord-stromal tumour of spindle cells with lipid and oestrogen production.

What concept does this question test?

It tests Systemic pathology: cardiovascular, respiratory, GI, renal, endocrine, CNS, bone and soft tissue in Pathology. Most are benign and found in postmenopausal women.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Systemic pathology: cardiovascular, respiratory, GI, renal, endocrine, CNS, bone and soft tissue?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.