Vesiculobullous disorders: complication of recessive dystrophic epidermolysis bullosa: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Vesiculobullous disorders: complication of recessive dystrophic epidermolysis bullosa

Sample item

A 28-year-old man with severe recessive dystrophic epidermolysis bullosa since childhood develops a nonhealing, indurated, ulcerated nodule on a chronically scarred forearm. What is the most likely diagnosis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Squamous cell carcinoma

Aggressive cutaneous squamous cell carcinoma develops in chronic wounds of severe recessive dystrophic epidermolysis bullosa and is a leading cause of death. A nonhealing nodule needs prompt biopsy.

Option by option

  • A. Basal cell carcinoma

    Basal cell carcinoma is not the typical tumour of chronic scarring wounds.

  • B. Pyogenic granuloma

    Pyogenic granuloma is a benign, friable vascular lesion, not an indurated nonhealing nodule.

  • C. Dermatofibroma

    Dermatofibroma is a benign firm papule that does not ulcerate.

  • D. Squamous cell carcinoma (correct)

    Correct. SCC arises in chronic scarred wounds of RDEB and behaves aggressively.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is D, Squamous cell carcinoma. Aggressive cutaneous squamous cell carcinoma develops in chronic wounds of severe recessive dystrophic epidermolysis bullosa and is a leading cause of death.

Why is "Basal cell carcinoma" not the answer?

Basal cell carcinoma is not the typical tumour of chronic scarring wounds.

Why is "Pyogenic granuloma" not the answer?

Pyogenic granuloma is a benign, friable vascular lesion, not an indurated nonhealing nodule.

Why is "Dermatofibroma" not the answer?

Dermatofibroma is a benign firm papule that does not ulcerate.

What concept does this question test?

It tests Vesiculobullous disorders: complication of recessive dystrophic epidermolysis bullosa in Dermatology. A nonhealing nodule needs prompt biopsy.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Vesiculobullous disorders: complication of recessive dystrophic epidermolysis bullosa?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.