Vesiculobullous disorders: BP180 NC16A ELISA in bullous pemphigoid: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Vesiculobullous disorders: BP180 NC16A ELISA in bullous pemphigoid

Sample item

A 75-year-old with bullous pemphigoid on treatment has anti-BP180 NC16A antibodies measured serially. What does a falling titre indicate?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Response to treatment and falling disease activity

Anti-BP180 NC16A antibody levels correlate with disease activity in bullous pemphigoid. A fall suggests remission and helps guide tapering of therapy.

Option by option

  • A. Transformation into dermatitis herpetiformis

    Dermatitis herpetiformis is associated with epidermal transglutaminase antibodies and gluten sensitivity.

  • B. Resistance to steroids

    A falling titre does not indicate steroid resistance.

  • C. Response to treatment and falling disease activity (correct)

    Correct. A falling anti-BP180 titre reflects reduced disease activity.

  • D. Development of pemphigus

    Pemphigus involves antibodies against desmogleins, not BP180.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is C, Response to treatment and falling disease activity. Anti-BP180 NC16A antibody levels correlate with disease activity in bullous pemphigoid.

Why is "Transformation into dermatitis herpetiformis" not the answer?

Dermatitis herpetiformis is associated with epidermal transglutaminase antibodies and gluten sensitivity.

Why is "Resistance to steroids" not the answer?

A falling titre does not indicate steroid resistance.

Why is "Development of pemphigus" not the answer?

Pemphigus involves antibodies against desmogleins, not BP180.

What concept does this question test?

It tests Vesiculobullous disorders: BP180 NC16A ELISA in bullous pemphigoid in Dermatology. A fall suggests remission and helps guide tapering of therapy.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Vesiculobullous disorders: BP180 NC16A ELISA in bullous pemphigoid?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.