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Dermatology · Pigmentary disorders: albinism and skin cancer
Sample itemA 25-year-old farm worker in India with oculocutaneous albinism has a scaly crusted ulcerated nodule on the sun-exposed scalp. What is the most likely diagnosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Squamous cell carcinoma
People with oculocutaneous albinism lack protective melanin and have a high risk of actinic keratoses and squamous cell carcinoma, which is the most common skin cancer in them. Strict photoprotection is advised.
Option by option
A. Seborrhoeic keratosis
Seborrhoeic keratosis is benign and not ulcerated.
B. Naevus
A naevus is a stable benign pigmented lesion.
C. Squamous cell carcinoma (correct)
Correct. Squamous cell carcinoma is the most common skin cancer in albinism.
D. Melanoma
Melanoma occurs but is less common than SCC in albinism.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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