Gynaecological oncology: sex cord stromal tumours: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Gynaecological oncology: sex cord stromal tumours

Sample item

A 55-year-old woman has postmenopausal bleeding and an adnexal mass. Histology shows coffee-bean nuclei with Call-Exner bodies. What is the tumour?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Granulosa cell tumour

Granulosa cell tumours secrete oestrogen, causing endometrial hyperplasia and bleeding, and produce inhibin. Call-Exner bodies are the histological hallmark.

Option by option

  • A. Dysgerminoma

    Dysgerminoma occurs in young women and is not oestrogenic.

  • B. Granulosa cell tumour (correct)

    Correct. Call-Exner bodies and oestrogen effects are typical.

  • C. Sertoli-Leydig cell tumour

    Sertoli-Leydig tumours cause virilisation.

  • D. Brenner tumour

    Brenner tumours show transitional epithelium with coffee-bean nuclei without Call-Exner bodies.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this OBG question

What is the answer to this OBG question?

The best answer is B, Granulosa cell tumour. Granulosa cell tumours secrete oestrogen, causing endometrial hyperplasia and bleeding, and produce inhibin.

Why is "Dysgerminoma" not the answer?

Dysgerminoma occurs in young women and is not oestrogenic.

Why is "Sertoli-Leydig cell tumour" not the answer?

Sertoli-Leydig tumours cause virilisation.

Why is "Brenner tumour" not the answer?

Brenner tumours show transitional epithelium with coffee-bean nuclei without Call-Exner bodies.

What concept does this question test?

It tests Gynaecological oncology: sex cord stromal tumours in OBG. Call-Exner bodies are the histological hallmark.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gynaecological oncology: sex cord stromal tumours?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.