Paediatric orthopaedics: osteogenesis imperfecta: practice question

A Orthopaedics question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Orthopaedics · Paediatric orthopaedics: osteogenesis imperfecta

Sample item

A child with blue sclerae, dentinogenesis imperfecta and recurrent fractures has severe disease. Which drug reduces the fracture rate?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Intravenous bisphosphonate

Osteogenesis imperfecta is a defect of type I collagen, and bisphosphonates reduce bone turnover, raise density and reduce fractures. Teriparatide is not used in growing children.

Option by option

  • A. Teriparatide

    Teriparatide is avoided in children with open physes.

  • B. Calcitriol alone

    Calcitriol alone does not correct the collagen defect.

  • C. Intravenous bisphosphonate (correct)

    Correct. Intravenous bisphosphonates are used in severe osteogenesis imperfecta.

  • D. Growth hormone

    Growth hormone has not been shown to reduce fractures.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Orthopaedics question

What is the answer to this Orthopaedics question?

The best answer is C, Intravenous bisphosphonate. Osteogenesis imperfecta is a defect of type I collagen, and bisphosphonates reduce bone turnover, raise density and reduce fractures.

Why is "Teriparatide" not the answer?

Teriparatide is avoided in children with open physes.

Why is "Calcitriol alone" not the answer?

Calcitriol alone does not correct the collagen defect.

Why is "Growth hormone" not the answer?

Growth hormone has not been shown to reduce fractures.

What concept does this question test?

It tests Paediatric orthopaedics: osteogenesis imperfecta in Orthopaedics. Teriparatide is not used in growing children.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Paediatric orthopaedics: osteogenesis imperfecta?

Pair each fracture with its classic complication and nerve injured. Then use the flashcards and the other Orthopaedics questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.