Haematology: AML genetics: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Haematology: AML genetics

Sample item

A 45-year-old has acute myeloid leukaemia with normal karyotype. Which mutation indicates a favourable prognosis if FLT3-ITD is absent?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. NPM1

NPM1 mutation without FLT3-ITD carries a favourable risk in cytogenetically normal AML. TP53 mutations carry a poor prognosis.

Option by option

  • A. ASXL1

    ASXL1 mutation is an adverse risk lesion.

  • B. NPM1 (correct)

    Correct. NPM1 mutation without FLT3-ITD gives a favourable outcome.

  • C. TP53

    TP53 mutation is a high risk adverse lesion.

  • D. RUNX1

    RUNX1 mutation is classified as an adverse risk lesion.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is B, NPM1. NPM1 mutation without FLT3-ITD carries a favourable risk in cytogenetically normal AML.

Why is "ASXL1" not the answer?

ASXL1 mutation is an adverse risk lesion.

Why is "TP53" not the answer?

TP53 mutation is a high risk adverse lesion.

Why is "RUNX1" not the answer?

RUNX1 mutation is classified as an adverse risk lesion.

What concept does this question test?

It tests Haematology: AML genetics in Pathology. TP53 mutations carry a poor prognosis.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Haematology: AML genetics?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.