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Radiology · Radiotherapy and nuclear medicine basics: nasopharyngeal carcinoma
Sample itemA man from north-east India has cervical nodes, serous otitis media and epistaxis. Biopsy shows non-keratinising nasopharyngeal carcinoma without distant spread. What is the primary treatment?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Radiotherapy with concurrent cisplatin
The nasopharynx is surrounded by the skull base and critical structures, and the tumour is radiosensitive, so concurrent chemoradiotherapy is the primary treatment. Surgery is reserved for selected recurrences, and chemotherapy or observation alone are inadequate.
Option by option
A. Radiotherapy with concurrent cisplatin (correct)
Correct. Radiotherapy with concurrent cisplatin is the primary treatment.
B. Radical nasopharyngectomy
Radical surgery is difficult at the skull base and is not first-line.
C. Chemotherapy alone
Chemotherapy alone cannot cure localised disease.
D. Observation
Observation allows progression of a curable tumour.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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