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OBG · Puerperium
Sample itemA 28-year-old woman had severe postpartum haemorrhage with shock. Six months later she has failure of lactation, amenorrhoea, fatigue and loss of pubic hair. What is the most likely diagnosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Sheehan syndrome
Severe obstetric haemorrhage with hypotension can cause ischaemic necrosis of the enlarged pituitary, giving hypopituitarism. The first sign is often failure to lactate, followed by amenorrhoea and secondary adrenal and thyroid failure. Diagnosis is confirmed by low pituitary hormones and imaging.
Option by option
A. Sheehan syndrome (correct)
Correct. Pituitary infarction after haemorrhage explains the loss of several hormone axes.
B. Polycystic ovary syndrome
PCOS causes oligomenorrhoea with hyperandrogenism, not hypopituitarism.
C. Premature ovarian insufficiency
Ovarian insufficiency would not cause lactation failure related to the haemorrhage or adrenal and thyroid failure.
D. Asherman syndrome
Asherman syndrome causes amenorrhoea from intrauterine adhesions but not lactation failure or hair loss.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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