Bone tumours: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Bone tumours

Sample item

A 28-year-old woman has pain near the knee. Radiograph shows an eccentric lytic lesion in the epiphysis reaching the subchondral bone. Histology shows numerous multinucleate giant cells among mononuclear stromal cells. What is the diagnosis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Giant cell tumour of bone

Giant cell tumour typically affects skeletally mature adults and arises in the epiphysis of long bones such as the distal femur and proximal tibia. It is locally aggressive and made of osteoclast-like giant cells with mononuclear neoplastic cells.

Option by option

  • A. Giant cell tumour of bone (correct)

    Epiphyseal eccentric lytic lesion in a young adult with osteoclast-like giant cells is classical.

  • B. Ewing sarcoma

    Ewing sarcoma is a small round cell tumour of children, mainly diaphyseal.

  • C. Osteoid osteoma

    Osteoid osteoma is a small cortical nidus with night pain relieved by aspirin.

  • D. Enchondroma

    Enchondroma is a cartilage lesion usually in small bones of the hands.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is A, Giant cell tumour of bone. Giant cell tumour typically affects skeletally mature adults and arises in the epiphysis of long bones such as the distal femur and proximal tibia.

Why is "Ewing sarcoma" not the answer?

Ewing sarcoma is a small round cell tumour of children, mainly diaphyseal.

Why is "Osteoid osteoma" not the answer?

Osteoid osteoma is a small cortical nidus with night pain relieved by aspirin.

Why is "Enchondroma" not the answer?

Enchondroma is a cartilage lesion usually in small bones of the hands.

What concept does this question test?

It tests Bone tumours in Pathology. It is locally aggressive and made of osteoclast-like giant cells with mononuclear neoplastic cells.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Bone tumours?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.