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Pathology · Lung pathology
Sample itemA retired shipyard worker has progressive dyspnoea. Imaging shows lower-zone interstitial fibrosis and calcified pleural plaques. Sputum shows golden-brown beaded rods with a translucent centre. What is the diagnosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Asbestosis
Asbestosis causes subpleural fibrosis predominantly in the lower lobes, with pleural plaques. Ferruginous bodies are asbestos fibres coated with iron-protein complexes.
Option by option
A. Berylliosis
Berylliosis shows non-caseating granulomas and is linked to aerospace and electronics work.
B. Silicosis
Silicosis favours the upper lobes with eggshell calcification of hilar nodes.
C. Coal worker's pneumoconiosis
Coal worker's pneumoconiosis involves the upper lobes with anthracotic pigment and no ferruginous bodies.
D. Asbestosis (correct)
Lower-lobe fibrosis, pleural plaques and ferruginous bodies point to asbestos exposure.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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