Cardiology: pulmonary arterial hypertension drugs: practice question

A General Medicine question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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General Medicine · Cardiology: pulmonary arterial hypertension drugs

Sample item

Which group of drugs is used specifically for pulmonary arterial hypertension?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Endothelin receptor antagonists, PDE-5 inhibitors and prostacyclin analogues

Bosentan, ambrisentan and macitentan block endothelin receptors, sildenafil and tadalafil inhibit PDE-5, and epoprostenol, treprostinil and selexipag act on the prostacyclin pathway. High-dose calcium channel blockers help only vasoreactive responders. Diuretics treat right heart failure symptoms.

Option by option

  • A. Endothelin receptor antagonists, PDE-5 inhibitors and prostacyclin analogues (correct)

    Correct. These are the three disease-targeted pathways.

  • B. Class I antiarrhythmics

    Antiarrhythmics do not treat PAH.

  • C. Loop diuretics only

    Diuretics are supportive only.

  • D. ACE inhibitors and beta blockers

    ACE inhibitors and beta blockers lack PAH efficacy.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this General Medicine question

What is the answer to this General Medicine question?

The best answer is A, Endothelin receptor antagonists, PDE-5 inhibitors and prostacyclin analogues. Bosentan, ambrisentan and macitentan block endothelin receptors, sildenafil and tadalafil inhibit PDE-5, and epoprostenol, treprostinil and selexipag act on the prostacyclin pathway.

Why is "Class I antiarrhythmics" not the answer?

Antiarrhythmics do not treat PAH.

Why is "Loop diuretics only" not the answer?

Diuretics are supportive only.

Why is "ACE inhibitors and beta blockers" not the answer?

ACE inhibitors and beta blockers lack PAH efficacy.

What concept does this question test?

It tests Cardiology: pulmonary arterial hypertension drugs in General Medicine. High-dose calcium channel blockers help only vasoreactive responders. Diuretics treat right heart failure symptoms.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Cardiology: pulmonary arterial hypertension drugs?

For each disease know the classic presentation, the best test, and the first-line treatment. Then use the flashcards and the other General Medicine questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.