Vascular disorders: Sneddon syndrome: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Vascular disorders: Sneddon syndrome

Sample item

A 35-year-old woman has livedo racemosa of the trunk and limbs and has had two ischaemic strokes. Which antibody should be sought?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Antiphospholipid antibodies

Sneddon syndrome combines livedo racemosa, a broken net pattern, with recurrent cerebrovascular events, and many patients have antiphospholipid antibodies. It is a thrombotic vasculopathy requiring anticoagulation in antibody-positive cases. Livedo racemosa is more pathological than the physiological livedo reticularis.

Option by option

  • A. Anti-desmoglein 3

    Anti-desmoglein 3 is seen in pemphigus vulgaris.

  • B. Antiphospholipid antibodies (correct)

    Correct. Antiphospholipid antibodies are associated with Sneddon syndrome.

  • C. Anti-Jo-1

    Anti-Jo-1 is linked to antisynthetase syndrome.

  • D. Anti-Scl-70

    Anti-Scl-70 is linked to diffuse systemic sclerosis.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is B, Antiphospholipid antibodies. Sneddon syndrome combines livedo racemosa, a broken net pattern, with recurrent cerebrovascular events, and many patients have antiphospholipid antibodies.

Why is "Anti-desmoglein 3" not the answer?

Anti-desmoglein 3 is seen in pemphigus vulgaris.

Why is "Anti-Jo-1" not the answer?

Anti-Jo-1 is linked to antisynthetase syndrome.

Why is "Anti-Scl-70" not the answer?

Anti-Scl-70 is linked to diffuse systemic sclerosis.

What concept does this question test?

It tests Vascular disorders: Sneddon syndrome in Dermatology. It is a thrombotic vasculopathy requiring anticoagulation in antibody-positive cases. Livedo racemosa is more pathological than the physiological livedo reticularis.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Vascular disorders: Sneddon syndrome?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.