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Dermatology · Vascular disorders: livedoid vasculopathy
Sample itemA 30-year-old woman has recurrent painful ulcers on the ankles each summer that heal leaving porcelain-white stellate scars with surrounding telangiectasia. Biopsy shows fibrin thrombi in dermal vessels without a vasculitic infiltrate. What is the best treatment approach?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Antiplatelet or anticoagulant therapy
Livedoid vasculopathy is a thrombo-occlusive disorder with painful ulcers that heal as atrophie blanche. Treatment addresses thrombosis with antiplatelets or anticoagulants such as rivaroxaban, and investigation for thrombophilia is advised. Immunosuppression is not the mainstay because there is no true vasculitis.
Option by option
A. Oral terbinafine
Terbinafine treats dermatophytosis.
B. High-dose systemic antibiotics
Antibiotics do not treat a thrombotic vasculopathy.
C. Antiplatelet or anticoagulant therapy (correct)
Correct. Antithrombotic therapy targets the pathology.
D. Cyclophosphamide
Cyclophosphamide is for true vasculitis.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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