Gynaecological oncology: hormone therapy after cervical cancer: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Gynaecological oncology: hormone therapy after cervical cancer

Sample item

A 38-year-old woman who underwent chemoradiation for squamous cervical cancer has premature ovarian failure with severe menopausal symptoms and bone loss. What is the advice about hormone therapy?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Hormone therapy is safe, since squamous cervical cancer is not hormone dependent, and it is needed to protect health

Squamous cervical carcinoma is not hormone sensitive, and women with premature ovarian failure after treatment benefit from hormone therapy until the usual age of menopause for bone, cardiovascular and symptom control. Oestrogen alone can be given after hysterectomy, and a progestogen is added if the uterus is present. Adenocarcinoma needs more caution.

Option by option

  • A. Hormone therapy is contraindicated for life

    There is no lifelong contraindication in squamous disease.

  • B. Use only herbal products

    Herbal products do not protect bone.

  • C. Only testosterone is allowed

    Testosterone is not a substitute for oestrogen replacement.

  • D. Hormone therapy is safe, since squamous cervical cancer is not hormone dependent, and it is needed to protect health (correct)

    Correct. Squamous cervical cancer is not hormone driven, so replacement is appropriate.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this OBG question

What is the answer to this OBG question?

The best answer is D, Hormone therapy is safe, since squamous cervical cancer is not hormone dependent, and it is needed to protect health. Squamous cervical carcinoma is not hormone sensitive, and women with premature ovarian failure after treatment benefit from hormone therapy until the usual age of menopause for bone, cardiovascular and symptom control.

Why is "Hormone therapy is contraindicated for life" not the answer?

There is no lifelong contraindication in squamous disease.

Why is "Use only herbal products" not the answer?

Herbal products do not protect bone.

Why is "Only testosterone is allowed" not the answer?

Testosterone is not a substitute for oestrogen replacement.

What concept does this question test?

It tests Gynaecological oncology: hormone therapy after cervical cancer in OBG. Oestrogen alone can be given after hysterectomy, and a progestogen is added if the uterus is present. Adenocarcinoma needs more caution.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gynaecological oncology: hormone therapy after cervical cancer?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.