Neuroimaging: schizencephaly: practice question

A Radiology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Radiology · Neuroimaging: schizencephaly

Sample item

A child with seizures and hemiparesis has MRI showing a cleft in the right cerebral hemisphere lined by grey matter that extends from the ventricle to the cortical surface. What is the diagnosis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Schizencephaly

Schizencephaly is a neuronal migration disorder with a full-thickness cleft lined by dysplastic grey matter, either open or closed lip. A porencephalic cyst is lined by white matter and gliosis instead.

Option by option

  • A. Lissencephaly

    Lissencephaly shows a smooth brain without gyri.

  • B. Porencephalic cyst

    A porencephalic cyst is lined by white matter, not grey matter.

  • C. Schizencephaly (correct)

    Correct. A grey matter-lined cleft from ventricle to cortex is schizencephaly.

  • D. Hydranencephaly

    Hydranencephaly shows near absence of the hemispheres replaced by CSF.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Radiology question

What is the answer to this Radiology question?

The best answer is C, Schizencephaly. Schizencephaly is a neuronal migration disorder with a full-thickness cleft lined by dysplastic grey matter, either open or closed lip.

Why is "Lissencephaly" not the answer?

Lissencephaly shows a smooth brain without gyri.

Why is "Porencephalic cyst" not the answer?

A porencephalic cyst is lined by white matter, not grey matter.

Why is "Hydranencephaly" not the answer?

Hydranencephaly shows near absence of the hemispheres replaced by CSF.

What concept does this question test?

It tests Neuroimaging: schizencephaly in Radiology. A porencephalic cyst is lined by white matter and gliosis instead.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Neuroimaging: schizencephaly?

Learn signs with the image, and the disease they point to. Then use the flashcards and the other Radiology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.