Papulosquamous: Wiskott-Aldrich syndrome: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Papulosquamous: Wiskott-Aldrich syndrome

Sample item

A male infant has eczema, recurrent infections and bleeding with petechiae. The platelets are small and low in number. What is the pattern of inheritance?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. X-linked recessive

Wiskott-Aldrich syndrome is an X-linked recessive disorder of WAS protein, with eczema, microthrombocytopenia and immune deficiency, and it predisposes to lymphoma and autoimmunity. Stem cell transplant is curative. The affected child is therefore male.

Option by option

  • A. Autosomal recessive

    Autosomal recessive inheritance does not apply.

  • B. Autosomal dominant

    Autosomal dominant inheritance does not apply.

  • C. Mitochondrial

    Mitochondrial inheritance does not apply.

  • D. X-linked recessive (correct)

    Correct. WAS is X-linked recessive.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is D, X-linked recessive. Wiskott-Aldrich syndrome is an X-linked recessive disorder of WAS protein, with eczema, microthrombocytopenia and immune deficiency, and it predisposes to lymphoma and autoimmunity.

Why is "Autosomal recessive" not the answer?

Autosomal recessive inheritance does not apply.

Why is "Autosomal dominant" not the answer?

Autosomal dominant inheritance does not apply.

Why is "Mitochondrial" not the answer?

Mitochondrial inheritance does not apply.

What concept does this question test?

It tests Papulosquamous: Wiskott-Aldrich syndrome in Dermatology. Stem cell transplant is curative. The affected child is therefore male.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Papulosquamous: Wiskott-Aldrich syndrome?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.