Neoplasia: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Neoplasia

Sample item

What tumor suppressor gene is commonly altered in retinoblastoma?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. RB gene

The core Neoplasia principle identifies RB gene as the best answer because it most directly explains the biochemical pathway or tissue response described in the stem.

Option by option

  • A. HBB gene

    HBB gene is relevant in another context but is not the best answer here.

  • B. FBN1 gene

    FBN1 gene does not account for the central finding in this sample.

  • C. RB gene (correct)

    Correct. RB gene is supported by the key clue given.

  • D. CFTR gene

    CFTR gene does not match the stated neoplasia mechanism.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is C, RB gene. The core Neoplasia principle identifies RB gene as the best answer because it most directly explains the biochemical pathway or tissue response described in the stem.

Why is "HBB gene" not the answer?

HBB gene is relevant in another context but is not the best answer here.

Why is "FBN1 gene" not the answer?

FBN1 gene does not account for the central finding in this sample.

Why is "CFTR gene" not the answer?

CFTR gene does not match the stated neoplasia mechanism.

What concept does this question test?

It tests Neoplasia in Pathology. The correct option holds because: Correct. RB gene is supported by the key clue given.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Neoplasia?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.