Amyloidosis: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Amyloidosis

Sample item

What property is demonstrated by amyloid on Congo red staining?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Apple-green birefringence

Amyloid deposits bind Congo red and show apple-green birefringence under polarized light because of their characteristic beta-pleated sheet structure.

Option by option

  • A. Blue-black iron staining

    Blue-black iron staining is associated with Prussian blue.

  • B. Apple-green birefringence (correct)

    Correct: Congo red with polarized light shows apple-green birefringence.

  • C. Acid-fast staining

    Acid-fast staining identifies organisms such as mycobacteria.

  • D. Gram-positive staining

    Gram stain categorizes bacteria by cell-wall properties.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is B, Apple-green birefringence. Amyloid deposits bind Congo red and show apple-green birefringence under polarized light because of their characteristic beta-pleated sheet structure.

Why is "Blue-black iron staining" not the answer?

Blue-black iron staining is associated with Prussian blue.

Why is "Acid-fast staining" not the answer?

Acid-fast staining identifies organisms such as mycobacteria.

Why is "Gram-positive staining" not the answer?

Gram stain categorizes bacteria by cell-wall properties.

What concept does this question test?

It tests Amyloidosis in Pathology. The correct option holds because: Correct: Congo red with polarized light shows apple-green birefringence.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Amyloidosis?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.