Inflammation: leukocyte adhesion: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Inflammation: leukocyte adhesion

Sample item

Rolling of neutrophils along activated endothelium is principally mediated by which molecules?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Selectins

Selectins mediate weak, transient tethering and rolling. Firm adhesion is mediated by leukocyte integrins binding endothelial ICAM-1 and VCAM-1.

Option by option

  • A. Cadherins

    Cadherins mediate cell-cell adhesion in tissues, not leukocyte rolling.

  • B. Integrins

    Integrins provide firm adhesion after chemokine activation.

  • C. Selectins (correct)

    Correct. Selectin bonds produce rolling under blood flow.

  • D. Collagen IV

    Collagen IV is a basement-membrane component.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is C, Selectins. Selectins mediate weak, transient tethering and rolling.

Why is "Cadherins" not the answer?

Cadherins mediate cell-cell adhesion in tissues, not leukocyte rolling.

Why is "Integrins" not the answer?

Integrins provide firm adhesion after chemokine activation.

Why is "Collagen IV" not the answer?

Collagen IV is a basement-membrane component.

What concept does this question test?

It tests Inflammation: leukocyte adhesion in Pathology. Firm adhesion is mediated by leukocyte integrins binding endothelial ICAM-1 and VCAM-1.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Inflammation: leukocyte adhesion?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.