Inflammation: complement: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Inflammation: complement

Sample item

Which complement fragment is a potent chemotactic factor for neutrophils?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. C5a

C5a recruits and activates neutrophils and also increases vascular permeability. C3b is a major opsonin, while C5b initiates membrane attack complex assembly.

Option by option

  • A. C3b

    C3b tags microbes for phagocytosis.

  • B. C5a (correct)

    Correct. C5a is strongly chemotactic and anaphylatoxic.

  • C. C1q

    C1q initiates the classical complement pathway.

  • D. C5b

    C5b begins membrane attack complex formation.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is B, C5a. C5a recruits and activates neutrophils and also increases vascular permeability.

Why is "C3b" not the answer?

C3b tags microbes for phagocytosis.

Why is "C1q" not the answer?

C1q initiates the classical complement pathway.

Why is "C5b" not the answer?

C5b begins membrane attack complex formation.

What concept does this question test?

It tests Inflammation: complement in Pathology. C3b is a major opsonin, while C5b initiates membrane attack complex assembly.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Inflammation: complement?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.