Gastrointestinal pathology: inflammatory bowel disease: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

Try it

Pathology · Gastrointestinal pathology: inflammatory bowel disease

Sample item

Transmural inflammation with skip lesions, fissures and noncaseating granulomas most strongly supports which diagnosis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Crohn disease

Crohn disease can affect any part of the gastrointestinal tract in discontinuous segments and is transmural, causing fistulae and strictures. Ulcerative colitis is continuous and limited to mucosa/submucosa of the colon.

Option by option

  • A. Crohn disease (correct)

    Correct. Transmural skip lesions and granulomas are classic Crohn features.

  • B. Irritable bowel syndrome

    Irritable bowel syndrome has no structural inflammatory lesion.

  • C. Ulcerative colitis

    Ulcerative colitis has continuous colonic mucosal disease.

  • D. Coeliac disease

    Coeliac disease causes villous atrophy in the small intestine.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is A, Crohn disease. Crohn disease can affect any part of the gastrointestinal tract in discontinuous segments and is transmural, causing fistulae and strictures.

Why is "Irritable bowel syndrome" not the answer?

Irritable bowel syndrome has no structural inflammatory lesion.

Why is "Ulcerative colitis" not the answer?

Ulcerative colitis has continuous colonic mucosal disease.

Why is "Coeliac disease" not the answer?

Coeliac disease causes villous atrophy in the small intestine.

What concept does this question test?

It tests Gastrointestinal pathology: inflammatory bowel disease in Pathology. Ulcerative colitis is continuous and limited to mucosa/submucosa of the colon.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gastrointestinal pathology: inflammatory bowel disease?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.