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Pathology · Liver pathology: chronic hepatitis
Sample itemBridging fibrosis with regenerative nodules is the defining architectural change of which condition?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Cirrhosis
Cirrhosis is diffuse hepatic fibrosis with conversion of normal architecture into structurally abnormal regenerative nodules. It results from chronic injury of many causes and causes portal hypertension.
Option by option
A. Cirrhosis (correct)
Correct. Fibrous septa plus regenerative nodules define cirrhosis.
B. Simple hepatic steatosis
Steatosis is intracellular lipid accumulation without established nodular architectural distortion.
C. Hepatic congestion only
Congestion alone does not define cirrhosis.
D. Acute viral hepatitis
Acute hepatitis can cause necrosis and inflammation but not established cirrhotic architecture.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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