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General Medicine · Infectious diseases: HIV
Sample itemWhich opportunistic infection is strongly associated with a CD4 count below 50 cells/mm3 in untreated HIV?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Cytomegalovirus retinitis
CMV retinitis becomes an important risk in advanced HIV with very low CD4 counts and can cause visual loss. Urgent ophthalmic assessment is needed for visual symptoms.
Option by option
A. Tuberculosis only
Tuberculosis can occur at a range of CD4 counts.
B. Uncomplicated impetigo
Impetigo is not the defining advanced-HIV opportunistic infection.
C. Cytomegalovirus retinitis (correct)
Correct. CMV retinitis is classically associated with profound CD4 depletion.
D. Streptococcal pharyngitis
Pharyngitis is common in the general population.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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