Immunodeficiency: Chediak-Higashi: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Immunodeficiency: Chediak-Higashi

Sample item

A child has recurrent pyogenic infections, partial albinism, peripheral neuropathy, and giant granules in leukocytes. What defect is likely?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Chediak-Higashi syndrome

Chediak-Higashi syndrome is a lysosomal trafficking defect causing impaired phagolysosome function, giant granules in leukocytes, partial albinism, and neuropathy. It can progress to an accelerated inflammatory phase.

Option by option

  • A. Bruton agammaglobulinemia

    Bruton disease causes absent mature B cells and recurrent bacterial infections.

  • B. Chediak-Higashi syndrome (correct)

    Correct. The combination of albinism and giant granules is distinctive.

  • C. DiGeorge syndrome

    DiGeorge syndrome causes T-cell deficiency with hypocalcemia and conotruncal defects.

  • D. Leukocyte adhesion deficiency

    LAD causes delayed cord separation and absent pus.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is B, Chediak-Higashi syndrome. Chediak-Higashi syndrome is a lysosomal trafficking defect causing impaired phagolysosome function, giant granules in leukocytes, partial albinism, and neuropathy.

Why is "Bruton agammaglobulinemia" not the answer?

Bruton disease causes absent mature B cells and recurrent bacterial infections.

Why is "DiGeorge syndrome" not the answer?

DiGeorge syndrome causes T-cell deficiency with hypocalcemia and conotruncal defects.

Why is "Leukocyte adhesion deficiency" not the answer?

LAD causes delayed cord separation and absent pus.

What concept does this question test?

It tests Immunodeficiency: Chediak-Higashi in Pathology. It can progress to an accelerated inflammatory phase.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Immunodeficiency: Chediak-Higashi?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.