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Dermatology · Infections: bacterial, viral, fungal, parasitic: candidal balanitis in diabetes
Sample itemA man with type 2 diabetes recently started on an SGLT2 inhibitor develops an itchy red glans with white patches and satellite pustules. What is the underlying mechanism?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Glycosuria favouring Candida overgrowth
SGLT2 inhibitors cause glucose to be excreted in the urine, providing a substrate for Candida in the moist subpreputial area. Genital candidiasis is a recognised adverse effect, and management is with topical antifungals and genital hygiene.
Option by option
A. Lichen sclerosus from low oestrogen
Lichen sclerosus produces white atrophic plaques and phimosis, without pustules.
B. Drug-induced fixed eruption
A fixed drug eruption gives a single well-defined dusky plaque, not satellite pustules.
C. Glycosuria favouring Candida overgrowth (correct)
Correct. Glycosuria feeds Candida under the foreskin, producing balanitis with satellite pustules.
D. Reactivation of herpes simplex
Herpes gives grouped vesicles and erosions, not diffuse erythema with satellite pustules.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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