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Dermatology · Infections: bacterial, viral, fungal, parasitic: one hand two feet syndrome
Sample itemA farmer has dry scaling of the right palm accentuated in the palmar creases, along with diffuse scaling of both soles. The left hand is normal. What is the most likely diagnosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Dermatophyte infection (tinea manuum and pedis)
Unilateral hand involvement with bilateral feet is the characteristic one hand two feet pattern, usually due to Trichophyton rubrum. Scraping for KOH examination confirms it, and oral terbinafine is often needed.
Option by option
A. Palmoplantar psoriasis
Palmoplantar psoriasis is typically symmetrical on both hands and feet.
B. Chronic hand eczema
Hand eczema is usually bilateral, with vesicles and fissures and no crease accentuation.
C. Dermatophyte infection (tinea manuum and pedis) (correct)
Correct. The asymmetric hand and symmetric feet is a typical dermatophyte pattern.
D. Keratolysis exfoliativa
Keratolysis exfoliativa gives superficial peeling in rings and is usually bilateral.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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