Skin tumours: infantile haemangioma marker: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Skin tumours: infantile haemangioma marker

Sample item

An infant has a bright red raised lesion that appeared at 3 weeks and is growing. Which immunohistochemical marker distinguishes this tumour from vascular malformations?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. GLUT1

Infantile haemangioma endothelial cells express GLUT1, which is absent in other vascular tumours and malformations. The lesion proliferates in the first months of life, then involutes over years. CD34 is expressed by endothelium generally and does not discriminate.

Option by option

  • A. CD34

    CD34 marks endothelium in many vascular lesions and does not discriminate.

  • B. GLUT1 (correct)

    Correct. GLUT1 positivity is characteristic of infantile haemangioma.

  • C. S100

    S100 marks melanocytic and neural lesions.

  • D. Factor XIIIa

    Factor XIIIa marks dermal dendrocytes in lesions such as dermatofibroma.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is B, GLUT1. Infantile haemangioma endothelial cells express GLUT1, which is absent in other vascular tumours and malformations.

Why is "CD34" not the answer?

CD34 marks endothelium in many vascular lesions and does not discriminate.

Why is "S100" not the answer?

S100 marks melanocytic and neural lesions.

Why is "Factor XIIIa" not the answer?

Factor XIIIa marks dermal dendrocytes in lesions such as dermatofibroma.

What concept does this question test?

It tests Skin tumours: infantile haemangioma marker in Dermatology. The lesion proliferates in the first months of life, then involutes over years. CD34 is expressed by endothelium generally and does not discriminate.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Skin tumours: infantile haemangioma marker?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.