Inflammation and repair: lipoxins and resolution: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Inflammation and repair: lipoxins and resolution

Sample item

During the resolution of acute inflammation, a class of arachidonic acid derivatives formed by transcellular biosynthesis inhibits neutrophil chemotaxis and adhesion. What are these mediators?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Lipoxins

Lipoxins are lipoxygenase products generated through interaction of leukocytes and platelets. They act as stop signals, inhibiting neutrophil recruitment and promoting monocyte entry and clearance of debris. Leukotrienes and most prostaglandins enhance rather than limit inflammation.

Option by option

  • A. Thromboxane A2

    Thromboxane A2 promotes platelet aggregation and vasoconstriction.

  • B. Leukotriene B4

    Leukotriene B4 is a potent neutrophil chemoattractant.

  • C. Lipoxins (correct)

    Correct. Lipoxins are anti-inflammatory and halt neutrophil recruitment.

  • D. Prostaglandin E2

    Prostaglandin E2 causes vasodilation, pain and fever and does not act as the stop signal.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is C, Lipoxins. Lipoxins are lipoxygenase products generated through interaction of leukocytes and platelets.

Why is "Thromboxane A2" not the answer?

Thromboxane A2 promotes platelet aggregation and vasoconstriction.

Why is "Leukotriene B4" not the answer?

Leukotriene B4 is a potent neutrophil chemoattractant.

Why is "Prostaglandin E2" not the answer?

Prostaglandin E2 causes vasodilation, pain and fever and does not act as the stop signal.

What concept does this question test?

It tests Inflammation and repair: lipoxins and resolution in Pathology. They act as stop signals, inhibiting neutrophil recruitment and promoting monocyte entry and clearance of debris. Leukotrienes and most prostaglandins enhance rather than limit inflammation.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Inflammation and repair: lipoxins and resolution?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.