Viral infections: epidermodysplasia verruciformis: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Viral infections: epidermodysplasia verruciformis

Sample item

A patient with an autosomal recessive mutation in EVER1/EVER2 has widespread flat warts and pityriasis versicolor-like plaques, with squamous carcinomas on sun-exposed skin. Which HPV types are mainly responsible?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. HPV 5 and 8

Epidermodysplasia verruciformis is an inherited susceptibility to beta-papillomaviruses, especially types 5 and 8. Sun exposure promotes malignant transformation to squamous cell carcinoma.

Option by option

  • A. HPV 6 and 11

    Types 6 and 11 cause genital warts.

  • B. HPV 1 and 4

    Types 1 and 4 cause plantar warts.

  • C. HPV 5 and 8 (correct)

    Correct. Types 5 and 8 are the oncogenic EV types.

  • D. HPV 16 and 18

    Types 16 and 18 cause anogenital cancers.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is C, HPV 5 and 8. Epidermodysplasia verruciformis is an inherited susceptibility to beta-papillomaviruses, especially types 5 and 8.

Why is "HPV 6 and 11" not the answer?

Types 6 and 11 cause genital warts.

Why is "HPV 1 and 4" not the answer?

Types 1 and 4 cause plantar warts.

Why is "HPV 16 and 18" not the answer?

Types 16 and 18 cause anogenital cancers.

What concept does this question test?

It tests Viral infections: epidermodysplasia verruciformis in Dermatology. Sun exposure promotes malignant transformation to squamous cell carcinoma.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Viral infections: epidermodysplasia verruciformis?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.