STI: reactive arthritis: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · STI: reactive arthritis

Sample item

A young man develops asymmetric knee arthritis, conjunctivitis and urethritis three weeks after a genital infection. Which HLA antigen is associated?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. HLA-B27

Reactive arthritis, formerly Reiter syndrome, is a seronegative arthritis after chlamydial or enteric infection with HLA-B27 association. Skin features include keratoderma blennorrhagicum and circinate balanitis.

Option by option

  • A. HLA-B5

    HLA-B5 (B51) is associated with Behcet disease.

  • B. HLA-DR4

    HLA-DR4 is associated with rheumatoid arthritis.

  • C. HLA-B27 (correct)

    Correct. HLA-B27 is the association.

  • D. HLA-DR3

    HLA-DR3 is associated with several autoimmune diseases such as SLE.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Dermatology questions

Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is C, HLA-B27. Reactive arthritis, formerly Reiter syndrome, is a seronegative arthritis after chlamydial or enteric infection with HLA-B27 association.

Why is "HLA-B5" not the answer?

HLA-B5 (B51) is associated with Behcet disease.

Why is "HLA-DR4" not the answer?

HLA-DR4 is associated with rheumatoid arthritis.

Why is "HLA-DR3" not the answer?

HLA-DR3 is associated with several autoimmune diseases such as SLE.

What concept does this question test?

It tests STI: reactive arthritis in Dermatology. Skin features include keratoderma blennorrhagicum and circinate balanitis.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study STI: reactive arthritis?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.