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Dermatology · STI: Mycoplasma genitalium
Sample itemA man has persistent urethritis after a course of doxycycline for presumed chlamydia, and tests for gonorrhoea and chlamydia are negative. Which organism, lacking a cell wall, is a likely cause?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Mycoplasma genitalium
Mycoplasma genitalium is a cell-wall-deficient bacterium that causes persistent or recurrent nongonococcal urethritis, with resistance to azithromycin and poor response to doxycycline. Moxifloxacin is used for resistant cases.
Option by option
A. Chlamydia trachomatis
Chlamydia typically responds to doxycycline and tested negative.
B. Trichomonas vaginalis
Trichomonas is a flagellate protozoan and not cell wall deficient.
C. Neisseria gonorrhoeae
Gonorrhoea tested negative.
D. Mycoplasma genitalium (correct)
Correct. M. genitalium commonly causes persistent NGU after doxycycline.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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