Nose: granulomatosis with polyangiitis: practice question

A ENT question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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ENT · Nose: granulomatosis with polyangiitis

Sample item

A patient has crusting nasal discharge, epistaxis, a saddle nose, haemoptysis and haematuria. Which serological marker is characteristic?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. c-ANCA (PR3)

Granulomatosis with polyangiitis (Wegener's) causes necrotising granulomas of the upper and lower respiratory tracts with glomerulonephritis, and c-ANCA directed against proteinase 3 is typical. Treatment is cyclophosphamide or rituximab with steroids.

Option by option

  • A. c-ANCA (PR3) (correct)

    Correct. c-ANCA to PR3 is typical.

  • B. Anti-dsDNA

    Anti-dsDNA is a marker of lupus.

  • C. p-ANCA (MPO)

    p-ANCA is associated with microscopic polyangiitis and EGPA.

  • D. Anti-centromere antibody

    Anti-centromere antibody marks limited scleroderma.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More ENT questions

Questions about this ENT question

What is the answer to this ENT question?

The best answer is A, c-ANCA (PR3). Granulomatosis with polyangiitis (Wegener's) causes necrotising granulomas of the upper and lower respiratory tracts with glomerulonephritis, and c-ANCA directed against proteinase 3 is typical.

Why is "Anti-dsDNA" not the answer?

Anti-dsDNA is a marker of lupus.

Why is "p-ANCA (MPO)" not the answer?

p-ANCA is associated with microscopic polyangiitis and EGPA.

Why is "Anti-centromere antibody" not the answer?

Anti-centromere antibody marks limited scleroderma.

What concept does this question test?

It tests Nose: granulomatosis with polyangiitis in ENT. Treatment is cyclophosphamide or rituximab with steroids.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Nose: granulomatosis with polyangiitis?

Learn tuning fork results and audiogram patterns by sketching them. Then use the flashcards and the other ENT questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.