Nose: NK/T-cell lymphoma: practice question

A ENT question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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ENT · Nose: NK/T-cell lymphoma

Sample item

A 40-year-old has progressive destruction of the midline nose and palate with necrotic ulceration and a negative ANCA. Biopsy shows angiocentric lymphoid infiltrate. Which virus is associated?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Epstein-Barr virus

Extranodal NK/T-cell lymphoma of nasal type causes midline destructive lesions (lethal midline granuloma) and is strongly associated with EBV. Treatment is radiotherapy combined with chemotherapy.

Option by option

  • A. Epstein-Barr virus (correct)

    Correct. EBV is tightly linked to nasal NK/T lymphoma.

  • B. Human papillomavirus

    HPV is linked to oropharyngeal cancers and papillomas.

  • C. Cytomegalovirus

    CMV does not cause this lymphoma.

  • D. Herpes simplex virus

    HSV causes mucocutaneous ulcers.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this ENT question

What is the answer to this ENT question?

The best answer is A, Epstein-Barr virus. Extranodal NK/T-cell lymphoma of nasal type causes midline destructive lesions (lethal midline granuloma) and is strongly associated with EBV.

Why is "Human papillomavirus" not the answer?

HPV is linked to oropharyngeal cancers and papillomas.

Why is "Cytomegalovirus" not the answer?

CMV does not cause this lymphoma.

Why is "Herpes simplex virus" not the answer?

HSV causes mucocutaneous ulcers.

What concept does this question test?

It tests Nose: NK/T-cell lymphoma in ENT. Treatment is radiotherapy combined with chemotherapy.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Nose: NK/T-cell lymphoma?

Learn tuning fork results and audiogram patterns by sketching them. Then use the flashcards and the other ENT questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.