Infertility: male hypogonadism: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Infertility: male hypogonadism

Sample item

A tall man with small firm testes, gynaecomastia and azoospermia has high FSH and LH and low testosterone. What is the karyotype?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. 47,XXY

Klinefelter syndrome (47,XXY) causes primary testicular failure with hyalinisation of seminiferous tubules. Hormone profile is hypergonadotropic hypogonadism. Infertility is managed with testicular sperm extraction and ICSI in selected men.

Option by option

  • A. 47,XXY (correct)

    Correct. Klinefelter syndrome is 47,XXY.

  • B. 47,XYY

    47,XYY does not cause hypogonadism.

  • C. 46,XY

    46,XY is a normal male karyotype.

  • D. 45,X

    45,X is Turner syndrome.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More OBG questions

Questions about this OBG question

What is the answer to this OBG question?

The best answer is A, 47,XXY. Klinefelter syndrome (47,XXY) causes primary testicular failure with hyalinisation of seminiferous tubules.

Why is "47,XYY" not the answer?

47,XYY does not cause hypogonadism.

Why is "46,XY" not the answer?

46,XY is a normal male karyotype.

Why is "45,X" not the answer?

45,X is Turner syndrome.

What concept does this question test?

It tests Infertility: male hypogonadism in OBG. Hormone profile is hypergonadotropic hypogonadism. Infertility is managed with testicular sperm extraction and ICSI in selected men.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Infertility: male hypogonadism?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.