Infertility: ovulation induction: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Infertility: ovulation induction

Sample item

Which drug is currently considered first-line for ovulation induction in women with PCOS?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Letrozole

Letrozole, an aromatase inhibitor, gives higher live birth rates than clomiphene in PCOS and is the recommended first-line agent. Clomiphene is an alternative. Gonadotrophins and laparoscopic ovarian drilling are second-line.

Option by option

  • A. Clomiphene citrate

    Clomiphene is second-line now.

  • B. hMG

    Gonadotrophins are second-line due to OHSS risk.

  • C. Letrozole (correct)

    Correct. Letrozole improves live birth in PCOS.

  • D. Bromocriptine

    Bromocriptine is for hyperprolactinaemia.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More OBG questions

Questions about this OBG question

What is the answer to this OBG question?

The best answer is C, Letrozole. Letrozole, an aromatase inhibitor, gives higher live birth rates than clomiphene in PCOS and is the recommended first-line agent.

Why is "Clomiphene citrate" not the answer?

Clomiphene is second-line now.

Why is "hMG" not the answer?

Gonadotrophins are second-line due to OHSS risk.

Why is "Bromocriptine" not the answer?

Bromocriptine is for hyperprolactinaemia.

What concept does this question test?

It tests Infertility: ovulation induction in OBG. Clomiphene is an alternative. Gonadotrophins and laparoscopic ovarian drilling are second-line.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Infertility: ovulation induction?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.