Gynaecological oncology: tamoxifen: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Gynaecological oncology: tamoxifen

Sample item

A woman on long-term tamoxifen for breast cancer develops postmenopausal bleeding. Which gynaecological risk is increased by tamoxifen?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Endometrial polyps and carcinoma

Tamoxifen acts as an oestrogen agonist on the endometrium, causing hyperplasia, polyps and a 2 to 3-fold rise in endometrial carcinoma. Any bleeding needs evaluation. Routine screening of asymptomatic women is not recommended.

Option by option

  • A. Vulval cancer

    Vulval cancer is not increased.

  • B. Endometrial polyps and carcinoma (correct)

    Correct. Tamoxifen stimulates the endometrium.

  • C. Ovarian cancer

    Ovarian cancer is not increased.

  • D. Cervical cancer

    Cervical cancer is not increased.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More OBG questions

Questions about this OBG question

What is the answer to this OBG question?

The best answer is B, Endometrial polyps and carcinoma. Tamoxifen acts as an oestrogen agonist on the endometrium, causing hyperplasia, polyps and a 2 to 3-fold rise in endometrial carcinoma.

Why is "Vulval cancer" not the answer?

Vulval cancer is not increased.

Why is "Ovarian cancer" not the answer?

Ovarian cancer is not increased.

Why is "Cervical cancer" not the answer?

Cervical cancer is not increased.

What concept does this question test?

It tests Gynaecological oncology: tamoxifen in OBG. Any bleeding needs evaluation. Routine screening of asymptomatic women is not recommended.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gynaecological oncology: tamoxifen?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.