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Dermatology · Infections: bacterial, viral, fungal, parasitic: Mycoplasma pneumoniae-induced rash and mucositis
Sample itemAn 11-year-old has had cough and fever for five days. He now has severe painful oral, ocular and genital erosions with only a few vesiculobullous skin lesions. He has taken no new drugs and the chest film shows a patchy infiltrate. What is the most likely diagnosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Mycoplasma pneumoniae-induced rash and mucositis
Mycoplasma pneumoniae-induced rash and mucositis presents with prominent mucositis and sparse skin lesions after a respiratory prodrome, mostly in children and young adults. There is no culprit drug, so the diagnosis rests on the infection, supported by Mycoplasma serology or PCR.
Option by option
A. Hand, foot and mouth disease
Hand, foot and mouth disease gives small oral ulcers and acral vesicles, not severe ocular and genital erosions.
B. Pemphigus vulgaris
Pemphigus vulgaris is rare in an 11-year-old, evolves over weeks and does not follow a respiratory illness.
C. Drug-induced Stevens-Johnson syndrome
Drug-induced SJS needs a culprit drug 1 to 3 weeks earlier and gives widespread targetoid lesions.
D. Mycoplasma pneumoniae-induced rash and mucositis (correct)
Correct. Prominent mucositis with sparse skin lesions after pneumonitis suggests Mycoplasma-induced rash and mucositis.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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