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Radiology · Neuroimaging: Rasmussen encephalitis
Sample itemA 7-year-old has intractable focal seizures with continuous twitching of the right hand and progressive right hemiparesis. Serial MRI over two years shows progressive atrophy of the left cerebral hemisphere. What is the diagnosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Rasmussen encephalitis
Rasmussen encephalitis is a chronic unihemispheric inflammatory process in children with refractory focal seizures, epilepsia partialis continua and progressive hemiparesis, with progressive unilateral cortical atrophy on MRI. Sturge-Weber has a facial naevus and gyriform calcification, and mesial temporal sclerosis is limited to the hippocampus.
Option by option
A. Mesial temporal sclerosis
Mesial temporal sclerosis shows hippocampal atrophy, not hemispheric atrophy.
B. Tuberous sclerosis
Tuberous sclerosis shows cortical tubers and subependymal nodules.
C. Rasmussen encephalitis (correct)
Correct. Progressive unilateral hemispheric atrophy with focal status is Rasmussen encephalitis.
D. Sturge-Weber syndrome
Sturge-Weber has a port-wine stain and tram-track calcification.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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