Gastrointestinal pathology: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Gastrointestinal pathology

Sample item

Familial adenomatous polyposis is caused by a germline mutation in which gene?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. APC

FAP follows germline loss of the APC tumour suppressor gene on chromosome 5q, causing hundreds to thousands of colonic adenomas and near-certain cancer without colectomy. TP53, KRAS and DCC are involved later in the adenoma-carcinoma sequence.

Option by option

  • A. KRAS

    KRAS mutation is an intermediate event in the sporadic sequence.

  • B. TP53

    TP53 mutation is a late event in sporadic colorectal cancer.

  • C. APC (correct)

    Correct. APC loss starts the adenoma sequence early and in many polyps.

  • D. DCC

    DCC loss is another late change in sporadic colorectal cancer.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is C, APC. FAP follows germline loss of the APC tumour suppressor gene on chromosome 5q, causing hundreds to thousands of colonic adenomas and near-certain cancer without colectomy.

Why is "KRAS" not the answer?

KRAS mutation is an intermediate event in the sporadic sequence.

Why is "TP53" not the answer?

TP53 mutation is a late event in sporadic colorectal cancer.

Why is "DCC" not the answer?

DCC loss is another late change in sporadic colorectal cancer.

What concept does this question test?

It tests Gastrointestinal pathology in Pathology. TP53, KRAS and DCC are involved later in the adenoma-carcinoma sequence.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gastrointestinal pathology?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.