Immunopathology: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Immunopathology

Sample item

What mechanism underlies type II hypersensitivity?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Antibodies against cell or matrix targets

Type II hypersensitivity involves IgG or IgM directed at cell-surface or extracellular matrix antigens, causing complement activation or altered receptor function.

Option by option

  • A. Antibodies against cell or matrix targets (correct)

    Correct: type II reactions use antibodies against fixed targets.

  • B. T-cell mediated cytotoxicity

    T-cell-mediated injury is type IV.

  • C. IgE-mediated mast-cell activation

    IgE-mediated mast-cell activation is type I.

  • D. Immune-complex deposition

    Immune-complex deposition is type III.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is A, Antibodies against cell or matrix targets. Type II hypersensitivity involves IgG or IgM directed at cell-surface or extracellular matrix antigens, causing complement activation or altered receptor function.

Why is "T-cell mediated cytotoxicity" not the answer?

T-cell-mediated injury is type IV.

Why is "IgE-mediated mast-cell activation" not the answer?

IgE-mediated mast-cell activation is type I.

Why is "Immune-complex deposition" not the answer?

Immune-complex deposition is type III.

What concept does this question test?

It tests Immunopathology in Pathology. The correct option holds because: Correct: type II reactions use antibodies against fixed targets.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Immunopathology?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.