Endocrine pathology: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Endocrine pathology

Sample item

What is the pathological mechanism of Graves disease?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. TSH-receptor stimulating autoantibodies

Graves disease is autoimmune hyperthyroidism caused by antibodies that stimulate the TSH receptor, increasing thyroid hormone production and gland growth.

Option by option

  • A. Iodine deficiency alone

    Iodine deficiency causes different goitre patterns.

  • B. Pituitary destruction causing low TSH

    Pituitary destruction causes secondary hypothyroidism.

  • C. Thyroid bacterial abscess

    Abscess is infectious thyroiditis.

  • D. TSH-receptor stimulating autoantibodies (correct)

    Correct: receptor-stimulating antibodies drive Graves hyperthyroidism.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is D, TSH-receptor stimulating autoantibodies. Graves disease is autoimmune hyperthyroidism caused by antibodies that stimulate the TSH receptor, increasing thyroid hormone production and gland growth.

Why is "Iodine deficiency alone" not the answer?

Iodine deficiency causes different goitre patterns.

Why is "Pituitary destruction causing low TSH" not the answer?

Pituitary destruction causes secondary hypothyroidism.

Why is "Thyroid bacterial abscess" not the answer?

Abscess is infectious thyroiditis.

What concept does this question test?

It tests Endocrine pathology in Pathology. The correct option holds because: Correct: receptor-stimulating antibodies drive Graves hyperthyroidism.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Endocrine pathology?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.