Hematology: hemolytic anemia: practice question

A General Medicine question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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General Medicine · Hematology: hemolytic anemia

Sample item

Which laboratory pattern supports hemolysis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Raised LDH, raised unconjugated bilirubin, low haptoglobin

Red-cell destruction releases LDH and heme, increasing unconjugated bilirubin, while haptoglobin is consumed binding free hemoglobin. Reticulocytosis is expected if marrow response is intact.

Option by option

  • A. Raised LDH, raised unconjugated bilirubin, low haptoglobin (correct)

    Correct. This combination is characteristic of hemolysis.

  • B. Low reticulocyte count with no bilirubin change

    Hemolysis usually stimulates reticulocytosis unless marrow response is impaired.

  • C. High ferritin alone

    Ferritin alone does not establish hemolysis.

  • D. Low LDH and high haptoglobin

    The opposite pattern does not support red-cell destruction.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this General Medicine question

What is the answer to this General Medicine question?

The best answer is A, Raised LDH, raised unconjugated bilirubin, low haptoglobin. Red-cell destruction releases LDH and heme, increasing unconjugated bilirubin, while haptoglobin is consumed binding free hemoglobin.

Why is "Low reticulocyte count with no bilirubin change" not the answer?

Hemolysis usually stimulates reticulocytosis unless marrow response is impaired.

Why is "High ferritin alone" not the answer?

Ferritin alone does not establish hemolysis.

Why is "Low LDH and high haptoglobin" not the answer?

The opposite pattern does not support red-cell destruction.

What concept does this question test?

It tests Hematology: hemolytic anemia in General Medicine. Reticulocytosis is expected if marrow response is intact.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Hematology: hemolytic anemia?

For each disease know the classic presentation, the best test, and the first-line treatment. Then use the flashcards and the other General Medicine questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.