Autoimmune disease: SLE: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Autoimmune disease: SLE

Sample item

Which hypersensitivity mechanism is most responsible for tissue injury in systemic lupus erythematosus?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Immune-complex deposition

Systemic lupus erythematosus involves autoantibody formation and immune-complex deposition in tissues, activating complement and causing inflammation such as nephritis and vasculitis.

Option by option

  • A. Defective collagen synthesis

    Collagen defects cause hereditary connective-tissue disorders.

  • B. Direct toxin exposure

    Toxin exposure is not the autoimmune mechanism.

  • C. Immune-complex deposition (correct)

    Correct. Immune complexes drive much SLE organ injury.

  • D. Immediate IgE-mediated allergy

    IgE-mediated allergy is type I hypersensitivity.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is C, Immune-complex deposition. Systemic lupus erythematosus involves autoantibody formation and immune-complex deposition in tissues, activating complement and causing inflammation such as nephritis and vasculitis.

Why is "Defective collagen synthesis" not the answer?

Collagen defects cause hereditary connective-tissue disorders.

Why is "Direct toxin exposure" not the answer?

Toxin exposure is not the autoimmune mechanism.

Why is "Immediate IgE-mediated allergy" not the answer?

IgE-mediated allergy is type I hypersensitivity.

What concept does this question test?

It tests Autoimmune disease: SLE in Pathology. The correct option holds because: Correct. Immune complexes drive much SLE organ injury.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Autoimmune disease: SLE?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.